ʻO kahi pale glycocalyx mānoanoa e kōkua i ka maʻi kanesa e pale aku i ka ʻōnaehana pale

ʻO kekahi ala e hūnā ai nā sela maʻi ʻaʻai mai ka ʻōnaehana pale o ke kino ma ka hana ʻana i kahi pale ʻili lahilahi i kapa ʻia ʻo glycocalyx. I loko o ka noiʻi hou, ua nānā nā mea noiʻi i nā waiwai waiwai o kēia pale me ka hoʻonā ʻike ʻole ʻia, me ka wehe ʻana i ka ʻike e hiki ke kōkua i ka hoʻomaikaʻi ʻana i nā immunotherapies cellular cancer o kēia manawa.
Hoʻokumu pinepine nā maʻi maʻi i kahi glycocalyx me nā kiʻekiʻe o nā mucins surface cell, i manaʻo ʻia e kōkua i ka pale ʻana i nā maʻi maʻi mai ka hoʻouka ʻana e nā cell immune. Eia nō naʻe, ua kaupalena ʻia ka ʻike kino o kēia pale, ʻoi aku ka pili o ka maʻi maʻi maʻi immunotherapy, e pili ana i ka wehe ʻana i nā cell immune mai ka mea maʻi, hoʻololi iā lākou e ʻimi a luku i ka maʻi kanesa, a laila hoʻohuli iā lākou i loko o ka mea maʻi.
"Ua ʻike mākou i ka hoʻololi ʻana i ka mānoanoa pale e like me ka liʻiliʻi e like me 10 nanometers e pili ana i ka hana antitumor o kā mākou mau cell immune a i ʻole immunotherapy engineered cell," wahi a Sangwu Park, he haumāna puka ma Matthew Paszek lab ma Cornell University ma ISAB, New York. "Ua hoʻohana mākou i kēia ʻike no ka hoʻolālā ʻana i nā cell immune e hiki ke hele i ka glycocalyx, a ke manaʻo nei mākou hiki ke hoʻohana ʻia kēia ala e hoʻomaikaʻi ai i ka immunotherapy cellular hou." Biology.
"Ua puka mai kā mākou lab i kahi hoʻolālā ikaika i kapa ʻia ʻo scanning angle interference microscopy (SAIM) e ana i ka nanosized glycocalyx o nā maʻi kanesa," wahi a Park. "Ua ʻae kēia ʻenehana kiʻi iā mākou e hoʻomaopopo i ka pilina pili o nā mucins pili i ke kanesa me nā waiwai biophysical o ka glycocalyx."
Ua hana nā mea noiʻi i kahi hiʻohiʻona kelepona e hoʻomalu pono i ka hōʻike ʻana o nā mucins surface cell e hoʻohālike i ka glycocalyx o nā maʻi kanesa. A laila hoʻohui lākou i ka SAIM me kahi ʻano genetic e noiʻi ai i ke ʻano o ka nui o ka ʻili, glycosylation, a me ka hoʻopili ʻana o nā mucins pili i ka maʻi kanesa e pili ana i ka mānoanoa pale nanoscale. Ua nānā pū lākou i ka hopena o ka mānoanoa o ka glycocalyx i ke kūʻē ʻana o nā cell e hoʻouka ʻia e nā cell immune.
Hōʻike ka haʻawina ʻo ka mānoanoa o ka glycocalyx cell cancer kekahi o nā ʻāpana nui e hoʻoholo ai i ka pale ʻana i nā cell immune, a ʻoi aku ka maikaʻi o nā cell immune engineered inā ʻoi aku ka lahilahi o ka glycocalyx.
Ma muli o kēia ʻike, ua hoʻolālā nā mea noiʻi i nā cell immune me nā enzyme kūikawā ma ko lākou ʻili e hiki ai iā lākou ke hoʻopili a pili pū me ka glycocalyx. Ua hōʻike ʻia nā hoʻokolohua ma ka pae cellular e hiki i kēia mau cell immune ke lanakila i ka pale kaua glycocalyx o nā maʻi kanesa.
Hoʻolālā ka poʻe noiʻi e hoʻoholo inā hiki ke hana hou ʻia kēia mau hopena i loko o ka lab a ma hope i nā hoʻokolohua lapaʻau.
E hōʻike ana ʻo Sangwoo Park i kēia haʻawina (hōʻuluʻulu manaʻo) i ka wā "Regulatory Glycosylation in the Spotlight" i ka lā Lāpule, Malaki 26, 2-3 pm PT, Seattle Convention Center, lumi 608. E kelepona i ka hui media no ka ʻike hou aku a i ʻole ka hele manuahi i ka ʻaha kūkā.
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